Indicators on phenobarbital sodium obat apa You Should Know
Indicators on phenobarbital sodium obat apa You Should Know
Blog Article
ADVERSE REACTIONS The following adverse reactions and their incidence were compiled from surveillance of Many hospitalized patients.
Contraindicated (one)pentobarbital will reduce the level or effect of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is to blame for the development and elimination of cariprazine's Energetic metabolites.
pentobarbital will lessen the level or effect of fludrocortisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will lessen the extent or effect of bazedoxifene/conjugated estrogens by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
Contraindicated (1)pentobarbital decreases levels of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers can decrease panobinostat amounts by ~70% and result in procedure failure.
pentobarbital will reduce the level or effect of cariprazine by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
Watch Intently (1)pentobarbital will decrease the level or effect of hydrocodone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Caution when discontinuing CYP3A4 inducers that are coadministered with hydrocodone; plasma concentrations of hydrocodone may possibly improve and may result in probably lethal respiratory depressionSerious - Use Alternative (one)hydrocodone, pentobarbital.
pentobarbital will lessen the extent or effect of suvorexant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Strong CYP3A4 inducers may well lower suvorexant efficacy; if improved suvorexant dose demanded, tend not to exceed twenty mg/day
pentobarbital will lower the extent or effect of netupitant/palonosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Netupitant is especially metabolized by CYP3A4; keep away from use in people who will be chronically using a strong CYP3A4 inducer
pentobarbital will reduce the level or effect of vincristine liposomal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Mysterious.
pentobarbital will lessen the level or effect of lonafarnib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is often a delicate CYP3A4 substrate. Coadministration with robust or reasonable CYP3A4 inducers is contraindicated.
pentobarbital will minimize the extent or effect of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Solid or moderate CYP3A4 inducers might raise charge of diazepam elimination; as a result, efficacy of diazepam can be decreased.
This mechanism is probably through the induction of hepatic microsomal enzymes that metabolize the antibiotic. If phenobarbital and doxycycline are administered concurrently, the medical response to get more info doxycycline must be monitored intently.
The sodium salt occurs to be a white, somewhat bitter powder and that is freely soluble in water and alcohol but almost insoluble in benzene and ether.